Мирцен
Монотерпен, присутствует во многих растениях
Выдержки из Pubmed
1991
https://www.ncbi.nlm.nih.gov/pubmed/1864266
Kauderer B1, Zamith H, Paumgartten FJ, Speit G. Evaluation of the mutagenicity of beta-myrcene in mammalian cells in vitro.
Результаты инвитро показали, что мирцен проявляет антимутагенные свойства.
1999
december
https://www.ncbi.nlm.nih.gov/pubmed/10606544
Sawamura M, Sun SH, Ozaki K, Ishikawa J, Ukeda H. Inhibitory effects of citrus essential oils and their components on the formation of N-nitrosodimethylamine.
Компоненты эфирных масел цитрусовых растений, такие как мирцен, альфа-терпинен, и терпинолен, оказывают ингибирующий эффект на формирование диметилнитрозамина
2003
august
https://www.ncbi.nlm.nih.gov/pubmed/12967039
Souza MC, Siani AC, Ramos MF, Menezes-de-Lima OJ, Henriques MG. Evaluation of anti-inflammatory activity of essential oils from two Asteraceae species.
Чистый бета-мирцен и лимонен ингибировали синтез оксида азота NO, а также гамма-интерферон и Интерлейкин-4
2008
september
https://www.ncbi.nlm.nih.gov/pubmed/19040104
Singh HP, Kaur S, Mittal S, Batish DR, Kohli RK. Phytotoxicity of major constituents of the volatile oil from leaves of Artemisia scoparia Waldst. & Kit.
The essential oil and the three monoterpenes exhibited phytotoxicity and reduced germination, seedling growth, chlorophyll content and percent respiration of Avena sativa and Triticum aestivum in a dose-response manner. The inhibitory effect of monoterpenes was comparatively smaller than of the crude essential oil and beta-myrcene was most toxic followed by p-cymene, whereas limonene was least toxic.
2009
january
https://www.ncbi.nlm.nih.gov/pubmed/19049815
Mitić-Culafić D, Zegura B, Nikolić B, Vuković-Gacić B, Knezević-Vukcević J, Filipic M. Protective effect of linalool, myrcene and eucalyptol against t-butyl hydroperoxide induced genotoxicity in bacteria and cultured human cells.
Linalool and myrcene strongly suppressed t-BOOH induced mutagenesis. Eucalyptol, in addition to moderate suppression of t-BOOH induced mutagenesis, suppressed also spontaneous mutagenesis. In NC-NC cells linalool and myrcene reduced t-BOOH induced DNA damage by about 50% at 0.01 microg/ml, while eucalyptol was less efficient (about 50% reduction at 1.0 microg/ml). The results indicate that linalool, eucalyptol and myrcene have substantial protective effect against oxidant induced genotoxicity, which is predominately mediated by their radical scavenging activity.
2011
june
https://www.ncbi.nlm.nih.gov/pubmed/21245202
Ciftci O, Ozdemir I, Tanyildizi S, Yildiz S, Oguzturk H. Antioxidative effects of curcumin, β-myrcene and 1,8-cineole against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in rats liver.
In contrast, curcumin, myrcene and cineole significantly increased GSH, CAT, GSH-Px and CuZn-SOD levels but decreased formation of TBARS. Additionally, the antioxidative effects of curcumin, myrcene and cineole were increased at day 60 compared to day 30. In the TCDD groups given curcumin, myrcene and cineole, oxidative stress decreased by time. In conclusion, curcumin, myrcene and cineole showed antioxidant activity and eliminated TCDD-induced oxidative stress in rats in a time-dependent manner.
2011
december
https://www.ncbi.nlm.nih.gov/pubmed/21450899
Ciftci O, Tanyildizi S, Godekmerdan A. Curcumin, myrecen and cineol modulate the percentage of lymphocyte subsets altered by 2,3,7, 8-tetracholorodibenzo-p-dioxins (TCDD) in rats.
In conclusion, curcumin, myrcene and cineol showed immunomodulatory effects and eliminated TCDD-induced immune suppressive effects in rats.
2012
august
https://www.ncbi.nlm.nih.gov/pubmed/22860587
Yvon Y, Raoelison EG, Razafindrazaka R, Randriantsoa A, Romdhane M, Chabir N, Mkaddem MG, Bouajila J. Relation between chemical composition or antioxidant activity and antihypertensive activity for six essential oils.
Significant correlation has been found for antihypertensive activity and p-cymene (R(2) = 0.86), β-elemene (R(2) = 0.90), and β-myrcene (R(2) = 0.76).
2014
april
https://www.ncbi.nlm.nih.gov/pubmed/24480520
Bonamin F, Moraes TM, Dos Santos RC, Kushima H, Faria FM, Silva MA, Junior IV, Nogueira L, Bauab TM, Souza Brito AR, da Rocha LR, Hiruma-Lima CA. The effect of a minor constituent of essential oil from Citrus aurantium: the role of β-myrcene in preventing peptic ulcer disease.
The results indicate that the oral administration of β-myrcene at a dose of 7.50mg/kg has important anti-ulcer activity with significantly decreased gastric and duodenal lesions as well as increased gastric mucus production. The results showed treatment with β-myrcene caused a significant increase in mucosal malondialdehyde level (MDA), an important index of oxidative tissue damage. The β-myrcene was also endowed with marked enhancement of antioxidant enzyme activity from GR system as evidenced by the decreased activity of superoxide dismutase (SOD) and increased levels of glutathione peroxidase (GPx), glutathione reductase (GR), and total glutathione in gastric tissue. Our results also shown that treatment with β-myrcene is not involved with thioredoxin reductase (TrxR) activity. Our results reveal, for the first time, the importance of β-myrcene as an inhibitor of gastric and duodenal ulcers and demonstrate that an increase in the levels of gastric mucosa defence factors is involved in the anti-ulcer activity of β-myrcene.
2014
september
https://www.ncbi.nlm.nih.gov/pubmed/24972849
Ciftci O, Oztanir MN, Cetin A. Neuroprotective effects of β-myrcene following global cerebral ischemia/reperfusion-mediated oxidative and neuronal damage in a C57BL/J6 mouse.
This study has demonstrated that MYR effectively attenuates oxidative and histological damage in the brain caused by global I/R. The beneficial effects of MYR probably contribute to its strong antioxidant and radical scavenging properties.
2015
march
https://www.ncbi.nlm.nih.gov/pubmed/25622554
Rufino AT, Ribeiro M, Sousa C, Judas F, Salgueiro L, Cavaleiro C, Mendes AF.Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis.
At non-cytotoxic concentrations, myrcene and limonene inhibited IL-1β-induced nitric oxide production (IC50=37.3μg/ml and 85.3µg/ml, respectively), but E-caryophyllene was inactive. Myrcene, and limonene to a lesser extent, also decreased IL-1β-induced NF-κB, JNK and p38 activation and the expression of inflammatory (iNOS) and catabolic (MMP-1 and MMP-13) genes, while increasing the expression of anti-catabolic genes (TIMP-1 and -3 by myrcene and TIMP-1 by limonene). Limonene increased ERK1/2 activation by 30%, while myrcene decreased it by 26%, relative to IL-1β-treated cells. None of the compounds tested was able to increase the expression of cartilage matrix-specific genes (collagen II and aggrecan), but both compounds prevented the increased expression of the non-cartilage specific, collagen I, induced by IL-1β. These data show that myrcene has significant anti-inflammatory and anti-catabolic effects in human chondrocytes and, thus, its ability to halt or, at least, slow down cartilage destruction and osteoarthritis progression warrants further investigation.
2016
july
https://www.ncbi.nlm.nih.gov/pubmed/27487280
Burcu GB, Osman C, Aslı C, Namik OM, Neşe BT. The protective cardiac effects of Β-myrcene after global cerebral ıschemia/reperfusion in C57BL/J6 mouse.
The administration of β-myrcene protects oxidative and histological damage in the heart tissue after global ischemia-reperfusion and may be useful safe alternative treatment for cardiac tissue after ischemic stroke.
2016
december
https://www.ncbi.nlm.nih.gov/pubmed/27543726
Uyeda S, Sharmin T, Satho T, Irie K, Watanabe M, Hosokawa M, Hiramatsu Y, Koga T, Nakashima Y, Kashige N, Toda A, Mishima K, Miake F. Enhancement and regulation effect of myrcene on antibody response in immunization with ovalbumin and Ag85B in mice.
Myrcene enhanced specific immune responses against OVA and Ag85B. This study suggested the tendency of the enhancement of Th1 immune response by myrcene.
2017
june
https://www.ncbi.nlm.nih.gov/pubmed/28659037
Hwang E, Ngo HTT, Park B, Seo SA, Yang JE, Yi TH. Myrcene, an Aromatic Volatile Compound, Ameliorates Human Skin Extrinsic Aging via Regulation of MMPs Production.
Furthermore, myrcene treatment (0.1-10[Formula: see text][Formula: see text]M) dramatically reduced the activation of MAPK-related signaling molecules such as p-ERK, p-p38, and p-JNK and AP-1 including p-c-Jun and p-c-Fos. Our data indicate that myrcene has a potential protective effect on UVB-induced human skin photoaging. Therefore, myrcene might have applications in the skincare industry.
Монотерпен, присутствует во многих растениях
Выдержки из Pubmed
1991
https://www.ncbi.nlm.nih.gov/pubmed/1864266
Kauderer B1, Zamith H, Paumgartten FJ, Speit G. Evaluation of the mutagenicity of beta-myrcene in mammalian cells in vitro.
Результаты инвитро показали, что мирцен проявляет антимутагенные свойства.
1999
december
https://www.ncbi.nlm.nih.gov/pubmed/10606544
Sawamura M, Sun SH, Ozaki K, Ishikawa J, Ukeda H. Inhibitory effects of citrus essential oils and their components on the formation of N-nitrosodimethylamine.
Компоненты эфирных масел цитрусовых растений, такие как мирцен, альфа-терпинен, и терпинолен, оказывают ингибирующий эффект на формирование диметилнитрозамина
2003
august
https://www.ncbi.nlm.nih.gov/pubmed/12967039
Souza MC, Siani AC, Ramos MF, Menezes-de-Lima OJ, Henriques MG. Evaluation of anti-inflammatory activity of essential oils from two Asteraceae species.
Чистый бета-мирцен и лимонен ингибировали синтез оксида азота NO, а также гамма-интерферон и Интерлейкин-4
2008
september
https://www.ncbi.nlm.nih.gov/pubmed/19040104
Singh HP, Kaur S, Mittal S, Batish DR, Kohli RK. Phytotoxicity of major constituents of the volatile oil from leaves of Artemisia scoparia Waldst. & Kit.
The essential oil and the three monoterpenes exhibited phytotoxicity and reduced germination, seedling growth, chlorophyll content and percent respiration of Avena sativa and Triticum aestivum in a dose-response manner. The inhibitory effect of monoterpenes was comparatively smaller than of the crude essential oil and beta-myrcene was most toxic followed by p-cymene, whereas limonene was least toxic.
2009
january
https://www.ncbi.nlm.nih.gov/pubmed/19049815
Mitić-Culafić D, Zegura B, Nikolić B, Vuković-Gacić B, Knezević-Vukcević J, Filipic M. Protective effect of linalool, myrcene and eucalyptol against t-butyl hydroperoxide induced genotoxicity in bacteria and cultured human cells.
Linalool and myrcene strongly suppressed t-BOOH induced mutagenesis. Eucalyptol, in addition to moderate suppression of t-BOOH induced mutagenesis, suppressed also spontaneous mutagenesis. In NC-NC cells linalool and myrcene reduced t-BOOH induced DNA damage by about 50% at 0.01 microg/ml, while eucalyptol was less efficient (about 50% reduction at 1.0 microg/ml). The results indicate that linalool, eucalyptol and myrcene have substantial protective effect against oxidant induced genotoxicity, which is predominately mediated by their radical scavenging activity.
2011
june
https://www.ncbi.nlm.nih.gov/pubmed/21245202
Ciftci O, Ozdemir I, Tanyildizi S, Yildiz S, Oguzturk H. Antioxidative effects of curcumin, β-myrcene and 1,8-cineole against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in rats liver.
In contrast, curcumin, myrcene and cineole significantly increased GSH, CAT, GSH-Px and CuZn-SOD levels but decreased formation of TBARS. Additionally, the antioxidative effects of curcumin, myrcene and cineole were increased at day 60 compared to day 30. In the TCDD groups given curcumin, myrcene and cineole, oxidative stress decreased by time. In conclusion, curcumin, myrcene and cineole showed antioxidant activity and eliminated TCDD-induced oxidative stress in rats in a time-dependent manner.
2011
december
https://www.ncbi.nlm.nih.gov/pubmed/21450899
Ciftci O, Tanyildizi S, Godekmerdan A. Curcumin, myrecen and cineol modulate the percentage of lymphocyte subsets altered by 2,3,7, 8-tetracholorodibenzo-p-dioxins (TCDD) in rats.
In conclusion, curcumin, myrcene and cineol showed immunomodulatory effects and eliminated TCDD-induced immune suppressive effects in rats.
2012
august
https://www.ncbi.nlm.nih.gov/pubmed/22860587
Yvon Y, Raoelison EG, Razafindrazaka R, Randriantsoa A, Romdhane M, Chabir N, Mkaddem MG, Bouajila J. Relation between chemical composition or antioxidant activity and antihypertensive activity for six essential oils.
Significant correlation has been found for antihypertensive activity and p-cymene (R(2) = 0.86), β-elemene (R(2) = 0.90), and β-myrcene (R(2) = 0.76).
2014
april
https://www.ncbi.nlm.nih.gov/pubmed/24480520
Bonamin F, Moraes TM, Dos Santos RC, Kushima H, Faria FM, Silva MA, Junior IV, Nogueira L, Bauab TM, Souza Brito AR, da Rocha LR, Hiruma-Lima CA. The effect of a minor constituent of essential oil from Citrus aurantium: the role of β-myrcene in preventing peptic ulcer disease.
The results indicate that the oral administration of β-myrcene at a dose of 7.50mg/kg has important anti-ulcer activity with significantly decreased gastric and duodenal lesions as well as increased gastric mucus production. The results showed treatment with β-myrcene caused a significant increase in mucosal malondialdehyde level (MDA), an important index of oxidative tissue damage. The β-myrcene was also endowed with marked enhancement of antioxidant enzyme activity from GR system as evidenced by the decreased activity of superoxide dismutase (SOD) and increased levels of glutathione peroxidase (GPx), glutathione reductase (GR), and total glutathione in gastric tissue. Our results also shown that treatment with β-myrcene is not involved with thioredoxin reductase (TrxR) activity. Our results reveal, for the first time, the importance of β-myrcene as an inhibitor of gastric and duodenal ulcers and demonstrate that an increase in the levels of gastric mucosa defence factors is involved in the anti-ulcer activity of β-myrcene.
2014
september
https://www.ncbi.nlm.nih.gov/pubmed/24972849
Ciftci O, Oztanir MN, Cetin A. Neuroprotective effects of β-myrcene following global cerebral ischemia/reperfusion-mediated oxidative and neuronal damage in a C57BL/J6 mouse.
This study has demonstrated that MYR effectively attenuates oxidative and histological damage in the brain caused by global I/R. The beneficial effects of MYR probably contribute to its strong antioxidant and radical scavenging properties.
2015
march
https://www.ncbi.nlm.nih.gov/pubmed/25622554
Rufino AT, Ribeiro M, Sousa C, Judas F, Salgueiro L, Cavaleiro C, Mendes AF.Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis.
At non-cytotoxic concentrations, myrcene and limonene inhibited IL-1β-induced nitric oxide production (IC50=37.3μg/ml and 85.3µg/ml, respectively), but E-caryophyllene was inactive. Myrcene, and limonene to a lesser extent, also decreased IL-1β-induced NF-κB, JNK and p38 activation and the expression of inflammatory (iNOS) and catabolic (MMP-1 and MMP-13) genes, while increasing the expression of anti-catabolic genes (TIMP-1 and -3 by myrcene and TIMP-1 by limonene). Limonene increased ERK1/2 activation by 30%, while myrcene decreased it by 26%, relative to IL-1β-treated cells. None of the compounds tested was able to increase the expression of cartilage matrix-specific genes (collagen II and aggrecan), but both compounds prevented the increased expression of the non-cartilage specific, collagen I, induced by IL-1β. These data show that myrcene has significant anti-inflammatory and anti-catabolic effects in human chondrocytes and, thus, its ability to halt or, at least, slow down cartilage destruction and osteoarthritis progression warrants further investigation.
2016
july
https://www.ncbi.nlm.nih.gov/pubmed/27487280
Burcu GB, Osman C, Aslı C, Namik OM, Neşe BT. The protective cardiac effects of Β-myrcene after global cerebral ıschemia/reperfusion in C57BL/J6 mouse.
The administration of β-myrcene protects oxidative and histological damage in the heart tissue after global ischemia-reperfusion and may be useful safe alternative treatment for cardiac tissue after ischemic stroke.
2016
december
https://www.ncbi.nlm.nih.gov/pubmed/27543726
Uyeda S, Sharmin T, Satho T, Irie K, Watanabe M, Hosokawa M, Hiramatsu Y, Koga T, Nakashima Y, Kashige N, Toda A, Mishima K, Miake F. Enhancement and regulation effect of myrcene on antibody response in immunization with ovalbumin and Ag85B in mice.
Myrcene enhanced specific immune responses against OVA and Ag85B. This study suggested the tendency of the enhancement of Th1 immune response by myrcene.
2017
june
https://www.ncbi.nlm.nih.gov/pubmed/28659037
Hwang E, Ngo HTT, Park B, Seo SA, Yang JE, Yi TH. Myrcene, an Aromatic Volatile Compound, Ameliorates Human Skin Extrinsic Aging via Regulation of MMPs Production.
Furthermore, myrcene treatment (0.1-10[Formula: see text][Formula: see text]M) dramatically reduced the activation of MAPK-related signaling molecules such as p-ERK, p-p38, and p-JNK and AP-1 including p-c-Jun and p-c-Fos. Our data indicate that myrcene has a potential protective effect on UVB-induced human skin photoaging. Therefore, myrcene might have applications in the skincare industry.
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